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Publications

Evaluation of the Ability of AlphaFold to Predict the Three-Dimensional Structures of Antibodies and Epitopes

Polonsky K, Pupko T, and Freund NT, Journal of immunology, November, 2023

β2-Adrenergic Signaling Promotes Higher-Affinity B cells and Antibodies.

Ben-Shalom N, Sandbank E, Abramovitz L, Hezroni H, Levin T, Trachtenberg E, Fogel N, Mor M, Yefet R, Stoler-Barak L, Hagin D, Nakai A, Msaki Noda M, Suzuki K, Ziv Shulman Z, Ben-Elyiahu S, and Freund NT, Brain Behavior and Immunity, July, 2023

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics.

Broketa M, Sokal A, Mor M, Canales-Herrerias P, Perima A, Meola A, Fernández I, Iannascoli B, Chenon G, Vandenberghe A, Languille L, Michel M, Godeau B, Gallien S, Melica G, Marija, Backovic M, Rey FA, Baudry J, Freund NT, Mahévas M and Bruhns P., JCI insight, June, 2023

Monkeypox Infection elicits strong Serological and B Cell response to A35R and H3L antigens. 

Yefet R, Friedel N, Tamir H, Polonsky K, Mor M, Hagin D, Schprecher E, Israely T and Freund NT, iScience, February, 2023

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies
 
 

Li R*, Mor M*, Ma B, Clark AE, Alter J, Werbner M, Lee JC, Leibel SL, Carlin AF, Dessau M, Gal-Tanamy M, Croker BA, Xiang Y, Freund NT. Communication Biology, 2022

Anti-TNFα Treatment Impairs Long-Term Immune Responses to COVID-19 mRNA Vaccine in Patients with Inflammatory Bowel Diseases
 
 

Rabinowitz KM*, Navon M*, Edelman-Klapper H, Zittan E, Bar-Gil Shitrit A, Goren I, Avni-Biron I, Ollech JE, Lichtenstein L, Banai-Eran H, Yanai H, Snir Y, Pauker MH, Friedenberg A, Levy-Barda A, Segal A, Broitman Y, Maoz E, Ovadia B, Aharoni Golan M, Shachar E, Ben-Horin S, Maharshak N, Mor M, Ben Zvi H, Eliakim R, Barkan R, Sharar-Fischler T, Goren S, Krugliak N, Pichinuk E, Mor M, Werbner M, Alter J, Abu-Taha H, Kaboub K, Dessau M, Gal-Tanamy M, Cohen D, Freund NT#, Dotan I#. Vaccines, 2022

Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα
 
 

Edelman-Klapper H, Zittan E, Bar-Gil Shitrit A, Rabinowitz KM, Goren I, Avni-Biron I, Ollech J, Lichtenstein L, Banai-Eran H, Yanai H, Snir Y, Pauker H M, Friedenberg A, Levy-Barda A, Segal A, Broytman Y, Maoz E, Ovadia B, Aharoni Golan M, Shachar E, Ben-Horin S, Maharshak N, Perets TT, Eliakim R, Goren S, Navon M, Krugliak N, Werbner M, Alter J, Dessau M, Gal Tanamy M, Freund NT, Cohen DI and Dotan I. Gastroenterology, 2021

Walking down the memory lane with SARS-CoV-2 B cells
 
 

Freund NT, Gerlic M & Croker B. Immunology and Cell Biology, 2021

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Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity
 
 

Hagin D*, Freund T*, Navon M*, Adir D, Halperin T, Marom R, Levi I, Benor S, Yifat Y, Ram R and Freund NT. Journal of Allergy and Clinical Immunology (JACI), 2021

 
Unleashing antibody repones against HIV-1
 
 

Ben-Shalom N & Freund NT. Cell Host & Microbe, 2021

 
Antibodies: what makes us stronger
 
 

Freund NT. Human Vaccines and Immunotherapeutics, 2021

 
Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors
 
 

Mor M, Werbner M, Alter L, Safra M, Chomsky E, Hada-Neeman S, Polonsky K, Nowell CJ, Clark AE, Roitburd-Berman A, Ben Shalom N, Navon M, Rafael D, Sharim H, Kiner E, Griffis E, Gershoni JM, Kobiler O, Lawrynowicz Leibel S, Zimhony O, Carlin AF, Yaari G, Dessau M, Gal-Tanamy M, Hagin D, Croker BA and Freund NT. PLoS Pathogens, 2021

 
Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature
 
 

Munitz, A. Edry‑Botzer L , Itan M, Tur‑Kaspa R, Dicker D, Marcoviciu D, Goren MG , Mor M, Lev S, Gottesman T, Muhsen K, Cohen D, Stein M, Qimron U, Freund NT , Wine Y & Gerlic M. Scientific Reports, 2021

Human antibodies targeting a mycobacterium transporter protein mediate protection against tuberculosis
 
 

Watson A, Li H, Ma B, Weiss R, Bendayan D, Abramovich L, Mordekovich M, Pinko E, Bar-Oz M, Wang Z, Du F, Lu Y, Rybniker J, Huang H, Barkan D, Xiang Y, Javid B & Freund NT. Nature Communications, 2021

 
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
 
 

Medina-Ramirez, Garces F, Escolano A, Skog P, de Taeye S, Moral-Sanchez ID, Dosenovic P, Hua Y, McGuire A, Gitlin A, Woude P, Freund NT, Yasmeen A, Behrens AJ, Ozorowski G, van den Kerkhof T, Sliepen K, Blane T, Kootstra N, van Breemen M, Pritchard L, Stanfield R, Crispin M, Ward A, Stamatatos L, Klasse P, ohn Moore J, Nemazee D, Nussenzweig MC, Wilson I, and Sanders RW. Journal of Experimental Medicine, 2017

 
Asymmetric recognition of HIV-1 Env trimer by V1V2 loop-targeting antibodies
 
 

Wang H, Gristick HB, Scharf L, West Jr. AP, Galimidi RP, Seaman MS, Freund NT, Nussenzweig MC. eLife, 2017

 
Co-existence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller
 
 

Freund NT, Haoqing H, Scharf L, Noguiera L, Horwitz JA, Sievers S, Sok D, Golijanin J, Halper-Stromberg A, West A, Lorenzi JC, Toth I, Piechocka-Torcha A, Wang LX, Seaman MS, Burton D, Gazumyan A, Walker BD, Bjorkman PJ & Nussenzweig MC. Science Translational Medicine, 2017

 
Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knock in mice
 
 

Escolano A, Steichen J, Dosenovic P, Kulp D, Golijanin J, Sok D, Freund NT, Araki T, Lowe S, Chen S, Heinemann J, Oliveira T, Gitlin A, Hui-Yao K, Georgeson E, Karen L, Francisco S, Gazumyan A, Burton D, Schief WR, Nussenzweig MC. Cell, 2017

 
HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
 
 

Steichen J.M, Kulp D.W, Tokatlian, T, Escolano A, Docenovic, P, Stanfield RL, McCoy L.E, Ozorowski G, Xiaozhen H, Kalyuzhniy, O, Briney B, Schiffner T, 0arces F, Freund NT, Gitlin, A, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan A, Yun D.S, Mayer C, Ward A, Burton D, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR. Immunity, 2016

 
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice
 
 

McGuire AT, Gray MD, Dosenovic P, Gitlin AD, Freund NT, Petersen J, Correnti C, Johnsen W, Kegel R, Stuart AB, Glenn J, Seaman MS, Schief WR, Strong RK, Nussenzweig MC, Stamatatos L. Nature Communications, 2016

A New glycan-dependent CD4-binding site neutralizing antibody exerts pressure on HIV-1 in vivo
 
 

Freund NT, Horwitz JA, Nogueira L, Sievers SA, Scharf L, Scheid JF, Gazumyan A, Liu C, Velinzon K, Goldenthal A, Sanders RW, Moore JP, Bjorkman PJ, Seaman MS, Walker BD, Klein F, Nussenzweig MC. PLoS Pathogens, 2015

 
Reconstitution of the receptor-binding motif of the SARS coronavirus
 
 

Freund NT, Roitburd-Berman A, Sui J, Marasco WA, Gershoni JM. Protein Engineering, Design and Selection, 2015

 
Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient
 
 

Freund NT, Scheid JF, Mouquet H, Nussenzweig MC. Journal of Immunological Methods, 2015

 
Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice

Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Björkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC. Cell, 2016

 
Phage display selection, analysis, and prediction of B cell epitopes
 
 

Gershoni JM.,  Roitburd-Berman A, Siman-Tov DD, Freund NT, Weiss Y. Current Protocols in Immunology, 2009

 
Epitope mapping - The first step in of epitope base vaccines
 
 

Gershoni JM.,  Roitburd-Berman A, Siman-Tov DD, Freund NT, Weiss Y. BioDrugs, 2007

 
Pepitope: epitope mapping from affinity-selected peptides
 
 

Mayrose I, Penn O, Erez E, Rubinstein ND, Shlomi T, Freund NT, Bublil EM, Ruppin E, Sharan R, Gershoni JM, Martz E, Pupko T. Bioinformatics, 2007

 
Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm
 
 

Bublil EM*, Freund NT*, Mayrose I, Penn O, Roitburd-Berman A, Rubinstein ND, Pupko T, Gershoni JM. Proteins: Structure, Function and Bioinformatics, 2007

 
Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides
 
 

Tarnovitski N, Matthews JL, Sui J, Gershoni MJ. Journal of Molecular Biology, 2006

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